Monday, 21 May 2018

The Nightmare Scenario For Genuine Chronic Pain Patients Has Arrived (Vid)

Today's post from kstp.com (see link below) may pretty well be the shape of things to come for chronic neuropathy sufferers who depend on opioids to control their pain and it's a horrifying prospect. You may well say that this is a localised set of guidelines in the USA but whatever happens in the States, tends to make its way across the world in due course. You can debate the arguments all you like but this set of guidelines is so strict that it verges on inhumane treatment of genuine patients. When the authorities see a drug as simply narcotics that are by definition evil, then you know that media hysteria has taken over from reason. The problem is that politicians jump on bandwagons as soon as they see a potential vote winner on the horizon and the nuances are simply ignored. There has to be accommodation for genuine patients with chronic pain conditions who depend on their medications to be able to live reasonably productive and normal lives. Take away the pain killers and you will see suffering on a hitherto unknown scale, all under the guise of protecting people from themselves. If you have severe neuropathy and are on opioid-family medications, you're going to need to fight for your rights to live relatively pain free. The onus is on the doctors to monitor and control their patients so that they don't become addicted and can switch/mix and match drugs when necessary, precisely to avoid that. That requires doctors to literally be on the case and not simply re-issue prescriptions ad infinitum. Genuine patients will do anything to avoid becoming addicted and don't ever want to be on opioids but they have no choice - everything else has failed and they need a carefully monitored medication program that combines holistic treatments and therapies...plus the drugs. That does not mean that the drugs should be taken away from the one week to the next. Draconian laws have never solved medication problems and they won't now. If ever we needed good advocacy, it's now!

Opioid Prescription Guidelines Now in Effect

 May 18, 2018 06:58 PM




3.5 million opioid prescriptions were written in Minnesota in 2016, and at least half of those pills ended up in the wrong hands, according to the Department of Human Services.

RELATED: Lawmakers Debate Opioid Taxes as States Grapple with Crisis


It's one reason new state guidelines were established to limit pills the number of being prescribed.

"These guidelines are really, really strict. They're the strictest I've ever seen," Dr. Mark Willenbring with Alltyr Clinic said.

He founded the St. Paul-based individualized treatment and therapy clinic about five years ago and has been studying addiction for nearly 40 years.

"I think we needed to cut back but I think we've cut back too far," he said of the state's new prescription guidelines that went into effect at the end of April.

In short, the guidelines outline three recommendations for providers:

1.) After an injury or surgery, avoid prescribing more than a three-day supply, or 20 pills.

2.) After that, prescribe opioids only for a seven-day time period and reassess.

3.) For chronic pain, avoid starting opioid therapy whenever possible and carefully manage any patient who remains on medication.

"I've got several patients right now that I'm maintaining on opioids for chronic pain and they're doing very well," Willenbring said. "Now, you take them off of that and they will not do well at all. They will go from 16 hours up and active a day to two hours up and active a day."

"These are narcotics," Acting Commissioner for the Department of Human Services Chuck Johnson said. "They change your brain chemistry so you use them enough over time, and you need to have more and more."

Johnson says the most dangerous period of time is within the first 45 days of use, and that addiction can happen within the first five days.

Minnesota Opioid Action Plan

"This isn't something that we're forcing on anyone," he said. "I think the whole healthcare industry and healthcare professionals are recognizing that there's a problem we need to address."

The state will monitor prescribers and flag those who stray from the guidelines, first working to help them adjust to the changes but will eventually impose repercussions if needed.

"If we have individuals who continue to overprescribe and not follow the guidelines, they could be removed as providers from our programs," Johnson said. That includes Medicaid and MinnesotaCare.

RELATED: Dayton Proposes Tax on Drug Companies in Effort to Combat Opioid Epidemic

"We cover about 20 percent of the state through our programs," he said.

"It's not going to do anything for the opioid problem in the state because the problem has shifted," Willenbring said. He believes the real problem lies with street drugs like heroin.

"It's mainly going to deprive people who need pain medication from getting it," he said.

The state can only oversee so much and is also working with individual health care providers to help monitor prescribers.

There are some exceptions to the guidelines. Examples include those who are addicted and depend on medically-assisted therapy, those in cancer treatment, and those in hospice care.

You can read more about the guidelines by clicking here.

Credits


Katherine Johnson


Updated: May 18, 2018 06:58 PM

Created: May 18, 2018 05:31 PM

http://kstp.com/medical/opioid-prescription-guidelines-now-in-effect/4913845/

Sunday, 20 May 2018

Childhood Cancer Treatment And Resulting Lifelong Neuropathy

Today's post from jamanetwork.com (see link below) makes for especially painful reading because you quickly realise that it actually concerns the future of neuropathy treatment and the sort of patients who may have to live with the symptoms for the rest of their lives. For children, the rest of their lives, is a very long time indeed! As adults, we know how difficult living with neuropathy is to manage - how difficult must it be for a child with both cancer and nerve damage! It makes you wonder if the sorts of chemotherapy that normally cause nerve damage, can't be substituted with less damaging forms but they've surely thought of that haven't they? The fact remains that childhood cancer is tragic enough without piling lifelong neuropathy symptoms on top - how cruel can life be!! Unfortunately, the fact also remains that without the chemotherapy treatment that can remove the cancer, the patient may die - so once again, they're left between a rock and a particularly hard place. Oh for that magic wand when you need it! It's a complex, heavyweight article but is worth the effort, if only to encourage us to push even harder for effective neuropathy research resulting in effective treatments.


Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer - Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes
May 14, 2018
Tejaswi Kandula, MBBS1,2; Michelle Anne Farrar, MBBS, PhD1,2; Richard J. Cohn, MBBCh3; et al David Mizrahi, MSc3,4; Kate Carey, PhD1; Karen Johnston, RNMN3; Matthew C. Kiernan, MBBS, PhD5; Arun V. Krishnan, MBBS, PhD6; Susanna B. Park, PhD5,6
Author Affiliations Article Information
JAMA Neurol. Published online May 14, 2018. doi:10.1001/jamaneurol.2018.0963


Key Points

Question What is the disease burden and functional effect of chemotherapy-induced peripheral neuropathy in childhood cancer survivors?

Findings In this cross-sectional study including 121 childhood cancer survivors, long-term deficits in clinical, electrophysiological, and functional measures of peripheral neuropathy were common, and concurrent deficits in patient-reported outcome measures suggest a significant effect. Cisplatin has a greater neurotoxicity profile than vinca alkaloids.

Meaning Both the type of neurotoxic agent used and a targeted clinical neurological assessment are important considerations when screening childhood cancer survivors for long-term neuropathy.

Abstract


Importance In light of the excellent long-term survival of childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality of life in long-term survivors.

Objective To comprehensively assess chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and to inform screening recommendations.

Design, Setting, and Participants In this cross-sectional observational study, cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years were recruited consecutively between April 2015 and December 2016 from a single tertiary hospital-based comprehensive cancer survivorship clinic and compared with healthy age-matched controls. Investigators were blinded to the type of chemotherapy. A total of 169 patients met inclusion criteria, of whom 48 (28.4%) were unable to be contacted or declined participation.

Exposures Chemotherapy agents known to be toxic to peripheral nerves.

Main Outcomes and Measures The clinical peripheral neurological assessment using the Total Neuropathy Score was compared between recipients of different neurotoxic chemotherapy agents and control participants and was correlated with neurophysiological, functional, and patient-reported outcome measures.

Results Of the 121 childhood cancer survivors included in this study, 65 (53.7%) were male, and the cohort underwent neurotoxicity assessments at a median (range) age of 16 (7-47) years, a median (range) 8.5 (1.5-29) years after treatment completion. Vinca alkaloids and platinum compounds were the main neurotoxic agents. Clinical abnormalities consistent with peripheral neuropathy were common, seen in 54 of 107 participants (50.5%) treated with neurotoxic chemotherapy (mean Total Neuropathy Score increase, 2.1; 95% CI, 1.4-2.9; P < .001), and were associated with lower limb predominant sensory axonal neuropathy (mean amplitude reduction, 5.8 μV; 95% CI, 2.8-8.8; P < .001). Functional deficits were seen in manual dexterity, distal sensation, and balance. Patient-reported outcomes demonstrating reduction in global quality of life and physical functioning were associated with the Total Neuropathy Score. Cisplatin produced long-term neurotoxicity more frequently than vinca alkaloids.

Conclusions and Relevance Clinical abnormalities attributable to peripheral neuropathy were common in childhood cancer survivors and persisted long term, with concurrent deficits in patient-reported outcomes. Both the type of neurotoxic agent and a targeted clinical neurological assessment are important considerations when screening survivors for long-term neuropathy. Further development of peripheral neuropathy–specific pediatric assessment tools will aid research into neuroprotective and rehabilitative strategies.

Introduction

The changing landscape of childhood cancer treatment over the last 6 decades has seen the improvement of childhood and adolescent cancer survival rates to 80% or greater for many cancer types.1,2 A child who survives 5 or more years after cancer diagnosis has a life span comparable with other persons of their age.3 In view of this excellent long-term survival, it is important to characterize the long-term morbidity from cancer treatment in the context of a significant burden of long-term health conditions in childhood cancer survivors (CCS).4-6

Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially long-lasting adverse effect of commonly used chemotherapy agents in pediatric practice, principally vincristine and other vinca alkaloids, cisplatin, and carboplatin.7 To our knowledge, long-term outcomes of peripheral neuropathy from these agents in children remain to be fully delineated. Neuromuscular impairment and restricted participation in daily activities are observed in CCS,8-10 and persistent deficits in fundamental motor skills are demonstrable in children following completion of cancer treatment.11 Multiple factors, such as obesity, poor bone health, and psychosocial health, may be part of a complex interaction that limits physical activity, which in turn perpetuates and maintains long-term health conditions.4,5,12,13 Chemotherapy-induced peripheral neuropathy may be a key factor contributing to reduced physical performance, and defining its effect is an important consideration in the design of any interventional programs. While other studies have demonstrated physical limitations in CCS,8,9,14,15 this study aims to extend these findings by providing a comprehensive multimodality evaluation of CIPN in long-term survivors of extracranial childhood cancer across multiple cancer types to define the disease burden and its functional effect as well as to inform recommendations for screening in this population.

Methods

Childhood cancer survivors treated with chemotherapy for extracranial malignancy before the age of 17 years at the Kids Cancer Centre, Sydney Children’s Hospital, Sydney, Australia, were recruited consecutively between April 2015 and December 2016 from the long-term follow-up clinic. Patients with other causes of peripheral neuropathy, such as diabetes, history of critical illness neuropathy, known inherited neuropathic conditions, or other neurodevelopmental disorders, were excluded. The study was approved by the Sydney Children’s Hospitals Network Human Research Ethics Committee. Written informed consent was obtained from each participant or their parent/guardian in accordance with the Declaration of Helsinki.

A comprehensive neurotoxicity assessment was carried out with each participant. For participants younger than 17 years, this included the pediatric-modified Total Neuropathy Score (TNS) for clinical measures, the Movement Assessment Battery for Children (MABC) for functional measures, nerve conduction studies for neurophysiological measures, and the Pediatric Quality of Life Inventory Generic Core Scales (PedsQL) and the Pediatric Outcomes Data Collection Instrument (PODCI) for patient-reported outcome (PRO) measures. For participants 17 years or older, this included the TNS clinical version for clinical measures, Von Frey monofilaments, grating orientation task, and grooved peg board task for functional measures, nerve conduction studies for neurophysiological measures, and the European Organisation for Research and Treatment of Cancer (EORTC) quality-of-life questionnaire and chemotherapy-induced peripheral neuropathy questionnaire (CIPN20) for PRO measures (eMethods and eTable 1 in the Supplement). Investigators were blinded to the type of chemotherapy.

Statistical analyses were conducted in consultation with a biostatistician using SPSS Statistics version 23 (IBM) and Prism version 7 (GraphPad). Comparisons used 2-tailed t tests and Mann-Whitney U tests for nonparametric subgroup analyses, χ2 tests for nominal data, 1-way analysis of variance for multiple groups, and Pearson or Spearman (small or ordinal data sets) correlations. Results are stated as means with standard deviations, and a P value less than .05 was considered significant. Bonferroni-corrected P values were used for correlations with multiple PROs.

Results were compared with healthy age-matched controls (age range, 6-56 years) or established population reference ranges for pediatric functional and PRO measures (eMethods and eTable 2 in the Supplement). In addition to group-level comparisons, individual item variance for each participant’s performance was calculated using the following formula: (control mean time − participant time) / control standard deviation. The 1-sample t test was used to compare the group variances with 0. The participant group mean was compared with the population mean and expressed as mean standard deviations above or below the population mean. Hierarchical linear regression models of neurophysiological and PRO measures with stepwise inclusion of predictive variables that may assist in screening CCS, including demographic, malignancy, and treatment variables, as well as concurrent clinical, neurophysiological, and functional outcomes were constructed to determine effect size (R2 increase) of each variable.

Results

A total of 169 patients met the inclusion criteria, of whom 48 (28.4%) were unable to be contacted or declined participation because of competing appointments or not wanting to participate in research. Neurotoxicity assessments were conducted in 121 CCS, of whom 65 (53.7%) were male, at a median (range) age of 16 (7.0-47.0) years, including 107 (88.4%) who received neurotoxic chemotherapy agents and 14 (11.6%) who received a protocol with no neurotoxic agents. Exposure to chemotherapy occurred a median (range) age of 4 (0-17.5) years, and the participants were tested a median (range) 8.5 (1.5-29.0) years after completion of their treatment (Table 1). Demographic characteristics are described for the entire cohort of 121 participants, but comparisons for all CIPN parameters were carried out between individual subgroups (ie, CCS who received neurotoxic chemotherapy vs controls or CCS who did not receive neurotoxic chemotherapy vs controls).

Radiotherapy exposure was seen in 50 of 107 CCS (46.7%) who received neurotoxic chemotherapy; 12 (11.2%) had cranial or craniospinal irradiation, 25 (23.4%) had extracranial involved-field irradiation, 12 (11.2%) had total body irradiation, and 1 (0.9%) had both cranial and total body irradiation. Additionally, 21 CCS (19.6%) who received neurotoxic chemotherapy also received a bone marrow transplant. Twenty CCS (18.7%) had a body mass index (calculated as weight in kilograms divided by height in meters squared) in the overweight category (>25), and 4 (3.7%) were in the obese category (>30).

Vinca alkaloids were the most commonly used neurotoxic chemotherapy agent and were used in 86 of 121 CCS (71.1%), of whom 81 (66.9%) received vincristine as the sole neurotoxic agent and 5 (4.1%) received multiple vinca alkaloids. Platinum agents were prescribed to 20 CCS (16.5%), including 7 (5.8%) who received cisplatin, 7 (5.8%) who received carboplatin, and 6 (5.0%) who received cisplatin and carboplatin; 7 (5.8%) were prescribed platinum agents as the only neurotoxic therapy and 13 (10.7%) were prescribed platinum agents in combination with vinca alkaloids. Thalidomide was the sole neurotoxic agent in 1 participant (0.8%). Numbers of patients, age, and sex distributions for the CCS and controls in the adult and pediatric age groups for each of the CIPN parameters are presented in eTable 2 in the Supplement.

Clinical Findings

Participants treated with neurotoxic chemotherapy demonstrated a significant increase in signs and symptoms of neuropathy as assessed via the TNS (mean [SD; range] score: CCS, 2.9 [3.2; 0-14]; controls, 0.8 [1.0; 0-4]; P < .001) (Table 2). Total Neuropathy Score abnormalities were present in 53 of 100 CCS (53.0%) treated with neurotoxic chemotherapy and 5 of 36 controls (14%). More prominent abnormalities of the peripheral clinical neurological assessment (TNS > 3) were more prevalent in CCS treated with a cisplatin-containing protocol (10 of 12 [83%]) compared with CCS treated with vinca alkaloids (23 of 80 [29%]), CCS treated with carboplatin without cisplatin (2 of 7 [29%]), CCS who did not receive any neurotoxic agents (2 of 13 [15%]), or controls (1 of 36 [3%]) (P = .001).

Neurophysiological Findings

The lower limb sural sensory amplitudes were smaller in CCS exposed to neurotoxic chemotherapy compared with age-matched controls (mean reduction, 5.8 μV; 95% CI, 2.8 to 8.8; P < .001) suggesting a reduced number of functioning axons (Table 2). In comparison, no significant reduction was seen in the sural amplitude in CCS not exposed to neurotoxic chemotherapy (mean reduction, 0.4 μV; 95% CI, −6.7 to 5.9; P = .90).

A sural amplitude below the mean (SD) control recording of 23.3 (7.8) μV was observed in 65 of 85 CCS (76%) treated with neurotoxic agents (Figure 1). Compared with population reference values, a sural amplitude below the age-appropriate reference ranges was noted in 20 CCS (24%) treated with neurotoxic chemotherapy (12 of 66 [18%] with vinca alkaloids and 7 of 18 [39%] with platinum agents).16-18 A total of 14 of 85 (16%) had an abnormal sural amplitude as well as an abnormal TNS, fulfilling criteria for peripheral neuropathy.19 No significant difference was observed in the sural sensory conduction velocity (0.9 m/s; 95% CI, −1.3 to 3.1; P = .40).

In contrast, there were no significant differences in motor amplitudes between CCS treated with neurotoxic agents and controls, including amplitudes from the tibial nerve to abductor hallucis (−0.4 mV; 95% CI, −2.0 to 1.2; P = .60) and the peroneal nerve to extensor digitorum brevis (−1.0 mV; 95% CI, −2.1 to 0.2; P = .09). Comparable values were also obtained for the upper limb median (SD) sensory amplitudes for CCS (60.2 [28.0] μV) and controls (61.6 [21.9] μV) (P = .80). Individually, compared with population reference ranges, abnormal values were seen in 1 of 85 CCS (1%) for tibial motor amplitude, 3 of 44 (7%) for peroneal motor amplitude, and 4 of 103 (3.9%) for median sensory amplitude. All but 1 CCS with abnormalities in other nerves also had an abnormal sural amplitude.

Functional Assessment Findings

In child and adolescent participants, there was no significant difference between CCS treated with neurotoxic agents and population references in the mean (SD) combined score percentiles of manual dexterity (43.2 [28.6]), aiming and catching (56.4 [30.1]), or balance (46.2 [31.8]) using the MABC. However, 2 of 3 individual manual dexterity tasks and 1 of 3 balance tasks demonstrated impairment in CCS (Table 2; Figure 2).

In adult participants, impaired performance was seen in the neurotoxic group compared with controls in distal sensory and motor tasks using Von Frey monofilaments testing light touch sensation (increased threshold, 0.1 mN; 95% CI, 0.03 to 0.2; P = .01), the grating orientation task testing cutaneous spatial resolution (increased threshold, 0.7 mm; 95% CI, 0.1 to 1.2; P = .003), and the grooved peg board testing manual dexterity (increased time to completion, 5.9 seconds; 95% CI, 1.6 to 10.1; P = .008) (Table 2; Figure 2). This translates to a difference of 0.4, 0.5, and 0.6 SDs, respectively, compared with controls. Additional matching for sex for the grooved peg board, given known sex differences in performance (eMethods in the Supplement) demonstrated a similar difference in the mean, which did not reach statistical significance in the context of a smaller sample size (increased time to completion, 4.7 seconds; 95% CI, 0.1 to 9.5; P = .06).

Comparison of CCS who did not receive any neurotoxic chemotherapy with controls did not demonstrate any functional differences except in the grating orientation task in the adult group (increased threshold, 0.5 mm; 95% CI, 0.003 to 1.0; P = .049). However, there were only small sample sizes in these subgroups (8 child and adolescent participants and 6 adult participants).

Patient-Reported Outcomes

Parent proxy reports for child and adolescent participants in the neurotoxic group demonstrated significant impairment and participation restriction across multiple domains, including the PedsQL physical domain (−0.4 SD; 95% CI, −0.6 to −0.1; P = .01) and psychosocial domain (−0.8 SD; 95% CI, −1.1 to −0.5; P < .001) and the PODCI sports and physical functioning domain (−0.4 SD; 95% CI, −0.8 to −0.1; P = .008). In comparison, child/adolescent self-report demonstrated impairment in the PedsQL psychosocial domain only (−0.3 SD; 95% CI, −0.5 to −0.05; P = .02) (eTable 3 in the Supplement).

In adult participants in the neurotoxic group, greater symptom report and poorer functioning and quality of life (QOL) were evident in all domains of the EORTC quality-of-life questionnaire (reduced physical functioning, 5.0 points; 95% CI, 0.9 to 9.1; P < .001) and CIPN20 questionnaire, except the autonomic symptom scale (increased neuropathy symptoms, 4.7 points; 95% CI, 1.2 to 8.2; P < .001) (eTable 3 in the Supplement). The 14 participants not exposed to chemotherapy (8 child and adolescent participants and 6 adult participants) were not different from controls in any of the domains.

Correlations

The clinical findings (TNS) were associated with the neurophysiological findings as well as the PRO measures for child and adolescent CCS (lower limb sural amplitude: Pearson correlation coefficient [r] = −0.33; P = .002; parent-reported PedsQL physical domain: Spearman correlation coefficient [rs] = −0.44; P < .001; parent-reported PedsQL psychosocial domain: rs = −0.43; P < .001; parent-reported PedsQL overall function domain: rs = −0.45; P < .001; parent-reported PODCI sport and physical function domain: rs = −0.31; P = .02; self-reported PedsQL physical domain: rs = −0.29; P = .03; self-reported PedsQL psychosocial domain: rs = −0.33; P = .01; self-reported PedsQL overall function domain: rs = −0.34; P = .01; and self-reported PODCI sport and physical function domain: rs = −0.38; P = .008). Notably, there was also a positive correlation between the parent-reported and self-reported overall function PedsQL (r = 0.66; P < .001) and PODCI sport and physical function (r = 0.66; P < .001) domains.

Adult and pediatric functional outcomes did not correlate with TNS, neurophysiological, or PRO measures. Importantly, no correlation was seen between vincristine dose and TNS or neurophysiological measures.

Risk Factors and Predictors


The TNS was the most significant predictive variable for PRO as well as neurophysiological outcomes, making it a valuable screening tool for CIPN-related deficits (Table 3). Following univariate analysis, radiotherapy (any location), sural amplitude, and TNS were the most probable significant predictors of PROs. Multivariate hierarchical linear regression demonstrated that the TNS was able to predict 25.6% of variability in parent-reported PedsQL scores (R2 = 0.38; β coefficient = −0.54; P < .001) and 22.6% in self-reported PedsQL scores (R2 = 0.24; β coefficient = −0.52; P = .001), 28.6% in parent-reported PODCI sport and physical function domain (R2 = 0.40; β coefficient = −0.57; P < .001), and 46.5% in the EORTC CIPN20 questionnaire (R2 = 0.47; β coefficient = 0.77; P < .001). The TNS was also the only significant predictor of neurophysiological (sural amplitude) outcomes, predicting 10% of the variability (R2 = 0.09; β coefficient = −0.32; P = .004) (Table 3). Importantly, age at diagnosis, time since completion of treatment, body mass index, type of malignancy, type of chemotherapy, and bone marrow transplantation were not predictive of neurophysiological or patient-reported deficits.

Discussion

Comprehensive, multimodal assessment of long-term survivors of extracranial childhood malignancy identified coherent abnormalities attributable to CIPN across objective and subjective measures. This study included participants who received multiple forms of treatment for a wide range of cancer types, increasing the generalizability of the findings. Clinical abnormalities are common and evident early in CCS and are accompanied by an overall reduction in the number of axons, manifesting as a length-dependent, predominantly sensory axonal neuropathy. Abnormalities are more prevalent following exposure to cisplatin, suggesting a greater neurotoxicity profile. Clinical abnormalities were correlated with deficits in PROs and QOL, suggesting that these changes are clinically relevant and important to monitor in CCS. There may be multiple risk factors that predispose CCS to the development of CIPN, including the type of neurotoxic agent and a genetic predisposition, and further delineation of these risk factors is critical to neuroprotective strategies.7,20 Recent evidence of benefit from targeted exercise intervention in pediatric inherited neuropathy provides the rationale for further similar therapeutic research in patients with CIPN.21

The widespread reduction in sural amplitude following exposure to neurotoxic chemotherapy, with 23.5% of CCS below population reference ranges, suggests an irreversible reduction in the number of functioning axons. This reduction is not evident in the CCS subgroup not exposed to neurotoxic chemotherapy. In contrast to the predominantly motor acute vincristine neuropathy reported in children,22,23 our study identified a predominantly sensory long-term neuropathy with both vinca alkaloids and platinum agents, similar to findings in adults.24 This may be due to lack of protection from the blood-nerve barrier in the sensory dorsal root ganglia25 as well as an underappreciation of acute sensory manifestations during chemotherapy treatment in the pediatric population. Additionally, long-term negative sensory symptoms, such as numbness, may not be recognized if present from an early age. Electrophysiological assessments by Jain et al26 within 3 years and by Ramchandren et al15 within 7 years after completion of treatment report a predominantly motor neuropathy. Both studies lacked a control group and used exceptionally broad reference ranges for the sural amplitude,27 which may have precluded the recognition of a sensory neuropathy. A larger study by Tay et al28 reported a mixed motor and sensory neuropathy 4 years after completion of vincristine treatment in 68.3% of patients. The predominantly sensory neuropathy that we observed in a smaller proportion of vincristine-treated participants at a longer median follow-up of 8.5 years suggests that neural recovery from acute vincristine injury occurs over several years and that motor nerves may recover better than sensory nerves. The concurrent presence of sensory neuropathy in all but 1 patient with abnormal motor studies in our cohort reinforces the long-term susceptibility of sensory nerves, with additional motor nerve involvement in some cases.

A key finding in this study is the greater long-term neurotoxicity of cisplatin compared with vinca alkaloids, previously underrecognized in the pediatric population.7 Young adults systematically assessed 13 years after treatment with cisplatin demonstrate long-term clinical sensory neuropathy in up to 72%,29-31 with little or no electrophysiological recovery.32,33 In comparison, 30% to 40% of adults treated with vincristine had symptoms or signs of neuropathy up to 3 years after completion of treatment, with continued long-term improvement and at least partial electrophysiological recovery.34,35 These differences in neurotoxicity profiles may be caused by differential underlying mechanisms. Platinum agents have been shown to be toxic to the cell bodies in the dorsal root ganglia, causing anterograde neuronal loss rather than the retrograde axonopathy described with vinca alkaloids, which may be more amenable to recovery.36,37 While carboplatin is generally considered less neurotoxic than cisplatin,38 some of the CCS receiving carboplatin had comparable neurotoxicity with those receiving cisplatin. However, its neurotoxicity in isolation is difficult to ascertain because of the small number of patients in this cohort receiving carboplatin alone.

The reduction in the number of residual axons in this cohort suggests a smaller axonal reserve following exposure to neurotoxic chemotherapy. The natural history of aging involves a reduction in axonal responses over the life span,17,39 which, in the context of a reduced axonal reserve, may confer a greater susceptibility to reduced function at an earlier age. Childhood cancer survivors are also at an increased risk of metabolic syndrome and diabetes.13,40,41 Diabetes is one of the leading causes of peripheral neuropathy worldwide, and it is being increasingly recognized that impaired glucose tolerance, prediabetes, metabolic syndrome, and obesity can also manifest peripheral neuropathy.42-44 Consequently, CCS may be at a greater risk of diabetic and prediabetic neuropathy, and this underscores the need for vigilance in this population as well as the importance of screening for early signs of peripheral neuropathy. Chemotherapy-induced peripheral neuropathy–related impediments in physical function may also result in a reduced inclination for regular exercise, adding a further metabolic and cardiovascular risk factor.

From a functional perspective, reduced manual dexterity and distal sensation were seen in children and adults on objective testing. Behavioral sciences literature suggests the use of 0.2, 0.5, and 0.8 SDs to demonstrate meaningful clinical differences of small, moderate, and large effect size, respectively. This would suggest that the 0.4 to 0.8 SD deficits observed in the generic health-related QOL and specific neuropathy parent-reported and patient-reported outcomes may have clinical relevance.45-48 However, the clinical significance of the 0.3 to 0.4 SD differences seen in the pediatric functional tasks and 0.4 to 0.6 SD differences in the adult functional tasks are more difficult to interpret. These relatively modest differences might reflect the large inbuilt reserve in pediatric nerves, and the implications of a reduction in this axonal reserve may only become evident with a longer period of observation as the current cohort gets older and potentially accumulates more neurological deficits, as observed in other CCS.49,50 

The stepwise acquisition of new skills during development in children might mean that more significant deficits would present with motor or sensory disability, whereas milder deficits may only present with a failure to achieve their premorbid potential rather than loss of skills. This change in developmental trajectory can be difficult to appreciate. As such, the PRO measures demonstrate global reduction in QOL and more specific impairment in physical function on the PODCI and EORTC questionnaires, suggesting that these deficits on formal testing may be relevant. Other studies have also reported deficits in strength and mobility,8,9,14 balance,51 and postural control52 as well as poorer QOL outcomes53 in CCS. However, the present study links CIPN-specific measures with long-term QOL, providing an important and comprehensive assessment of the association of long-term neuropathy with patient function. Importantly, we have demonstrated the TNS as a significant predictor of adult and pediatric PROs. While deficits evident in functional measures and PROs may be multifactorial, the TNS was specifically designed to capture peripheral neurotoxicity, has been validated against multiple neuropathy measures,54-56 and is correlated with objective neurophysiological measures in CCS, enabling greater confidence in attributing abnormalities to peripheral neuropathy. The TNS is based solely on clinical assessment and has less interindividual variability than neurophysiological testing, making it a valuable screening tool to identify patients at higher risk of disability from peripheral neuropathy.

Limitations

This study had limitations. Although tested several years after completion of their chemotherapy, it is unlikely that participants developed peripheral nerve injury from other causes during this time, given the young age of the cohort. Furthermore, comorbidities and preexisting conditions known to cause nerve injury, such as diabetes, renal failure, and critical illness neuropathy, were specific exclusion criteria. While there is a wide range of time elapsed since completion of treatment among the survivors, the median time since completion of treatment is 8.5 years. Late onset of neurological deficits with an increase in cumulative incidence up to 30 years after completion of therapy has been observed in large databases of CCS49,50 and may be compounded by additional comorbidities that occur as late effects. The administration of different functional and PRO measures for adults and children limited the numbers of participants in some subgroups, including CCS who did not receive any neurotoxic chemotherapy. Further studies are required to develop a greater understanding of CIPN in high-risk CCS, particularly those treated with platinum agents. The functional and PRO measures used in the pediatric participants were not specifically designed for use in CIPN, and only a subset of MABC measures identified functional impairments. As such, the development of responsive, pediatric CIPN–specific outcomes measures would be important for further clinical research into neuroprotective strategies and exercise interventions.

Conclusions


Long-term deficits in clinical, electrophysiological, and functional measures of peripheral neuropathy were common in our young cohort of CCS with concurrent deficits in PRO measures. Multimodal testing with inclusion of objective neurophysiological measures and subjective PRO measures is important to be able to attribute abnormalities to CIPN and determine their clinical relevance. Both the type of neurotoxic agent used and a targeted clinical neurological assessment are important considerations when screening CCS for long-term neuropathy. The effect of CIPN may be greater in the presence of other comorbidities, such as diabetes, and also as CCS get older. Development of standardized, CIPN-specific pediatric assessment tools, further research into the acute development and progression of neuropathy, and delineation of genetic and nongenetic predisposing factors are essential for the development of neuroprotective interventional, and rehabilitative strategies to optimize the long-term QOL for CCS.
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Article Information

Accepted for Publication: February 16, 2018.


Corresponding Author: Susanna B. Park, PhD, Brain and Mind Centre, Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, Sydney, New South Wales 2050, Australia (susanna.park@sydney.edu.au).

Published Online: May 14, 2018. doi:10.1001/jamaneurol.2018.0963

Author Contributions: Dr Kandula had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Kandula, Farrar, Cohn, Johnston, Kiernan, Krishnan, Park.

Acquisition, analysis, or interpretation of data: Kandula, Farrar, Cohn, Mizrahi, Carey, Johnston, Kiernan, Park.

Drafting of the manuscript: Kandula, Cohn, Kiernan, Park.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Kandula, Park.

Obtained funding: Kandula, Kiernan, Krishnan.

Administrative, technical, or material support: Farrar, Cohn, Mizrahi, Carey, Johnston.

Study supervision: Farrar, Cohn, Kiernan, Park.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was funded by grant APP1114801 from the National Health and Medical Research Council and grant 14/TPG/1-05 from the Cancer Institute of New South Wales as well as by the Royal Australasian College of Physicians and Brain Sciences UNSW of the University of New South Wales Sydney.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: We acknowledge Nancy Briggs, BS, MA, PhD (Stats Central, University of New South Wales Sydney, Sydney, New South Wales, Australia), for guidance with statistical analyses. She was not compensated for her work.

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https://jamanetwork.com/journals/jamaneurology/fullarticle/2680670

Saturday, 19 May 2018

Neuropathy: Accepting It Is Only The First Hurdle

Today's post from themighty.com (see link below) makes your heart sink to your stomach because it describes a reality of living with neuropathy that so many millions across the world will recognise and it ain't pretty! This sort of story describes the dichotomy of neuropathy perfectly: those with it, know exactly what the writer means and those free of nerve damage, wonder what all the fuss is about and launch into 'negativity-spirals' lectures and stigmas. There is such a gulf of understanding between those who know what the symptoms of nerve pain feel like and those who want to be sympathetic but can't because...well frankly, there's nothing else like it! So who does this story benefit? Well, those living with neuropathy will be comforted by the fact that they're not alone and maybe relieved by the fact that their neuropathy isn't quite as bad as this person's. Will it benefit anyone else? The medical profession for instance, who understand the technicalities but have no idea what neuropathy feels like? Or maybe, friends, family and co-workers, who genuinely want to know what's going on? The problem is that everybody knows what a toothache, or a headache, or a burn, or any other universal condition feels like but unless you suffer from neuropathy, you cannot really sympathise or empathise because, neuropathy's uniqueness is that it's simply a bitch...there, I said it!


What I'm Learning as I Start My First Day of Long-Term Medical Leave
Kevin Beck Contributor  5th May 2018


Today is the first day of my long-term medical leave. I’m a teacher, but peripheral neuropathy and erythromelalgia have forced me to take all of my sick leave for the remainder of the school year. In addition, my school district has a policy that allows me to take one year of unpaid leave next year. I need it, but it has taken me a long time to accept this reality.

I have struggled with chronic pain every day for what seems like an eternity. It’s really more like a series of eternities with each day being an endless, fiery hell.

The pain scale has become meaningless to me. How can you measure your pain when it relentlessly stabs, burns, tingles, swells, shocks, and aches? How do you tell someone that you pray your pain would come down to a 10 without seeming like you’re exaggerating?

With enflamed soles, I couldn’t teach standing up. With stinging feet, I couldn’t teach sitting down. With legs that felt like sandbags, I needed a cane to help me walk and keep my balance. Throughout this school year, I took off my shoes and socks and taught barefoot because of the burning. Every step felt like running a marathon on hot coals. However, pain was not my only battle.

It has taken over a year to get a diagnosis, but not for a lack of trying. Thankfully, I have been blessed with caring doctors and nurses who went the extra mile to help me. They have listened sympathetically and sought a correct diagnosis and treatment to relieve my struggles. Nevertheless, the journey to receiving a diagnosis has been agonizing.

Between my primary care nurse practitioner, two neurologists, pulmonologist, dermatologist, and palliative care specialist, we have gone through multiple diagnoses and potential causes. First was multiple sclerosis, but the MRI came back negative. Then it was small fiber neuropathy possibly caused by sarcoidosis. When that didn’t pan out, the diagnosis became idiopathic small fiber neuropathy.

All of these false starts costed time, money, and hope. Now, after several months and thousands of dollars of tests, we finally landed on the diagnosis of peripheral neuropathy and erythromelalgia. Of course, as I’ve learned, this is all subject to change.

Even as I write, the pain coupled with doctor visits, weening off one set of meds so I can try others, waiting for test results, and constant uncertainty brings intense emotional distress that exacerbates my diagnosed depression and anxiety.

Can’t anyone help? Can’t anyone say, “This is what’s wrong, and this is how we can treat it?”

Headed into this school year, I feared the possibility that I wouldn’t finish. Now my fear has become a reality. I fought my struggles every day, and the intense pain even caused me to lose the ability to stand on some days. I promised myself, though, that I wouldn’t quit. I would keep on working until they dragged me out.

My desire to force my body into submission affected my family. They help me stand, walk, and get dressed. They watch me lay on the couch, exhausted and unable to roll over. And until today, they knew I would go back to work.

Why would I be so harsh on myself and them? I’ve taught several students with disabilities, and I’ve worked to successfully accommodate their needs. I never judged them, looked down on them, or considered them a burden.

Why, then, did I have such trouble coming to terms with my own needs?

Shortly after returning from winter break, a close friend and colleague gently told me that my pride was getting in the way of my health and my family’s wellbeing. She said that I did not want to admit that I was becoming disabled. My ego was causing me to go on a forced march when my body could not cooperate. My desire to be someone other than who I am brought unnecessary harm to me and my loved ones.

This was hard to hear, but I needed that straightforward talk in order find the courage to make a necessary decision. I made an appointment with the human resources department to ask about taking some time off. Once again, I found a caring and supportive staff that guided me through the Byzantine process of applying for medical leave and disability.

My application for taking this year and next year off was approved almost immediately, and now I have a year an a half to focus in my health – for my good, the good of my family, and the good of any students I may have if I can ever go back to the classroom.

I have struggled to realize that my worth as a person cannot be measured by how much I work. Being disabled and unable to work does not mean I’m worthless. Not awaking every morning to go to a job does not make me lazy. Needing to take care of myself doesn’t suggest selfishness, weakness, or apathy. Instead, to confess that I needed help took courage, honesty, and strength.

So now what do I do? Just sit around the house in my pajamas? Take a nap? Do nothing? Well, yes. At least for today and maybe for a while to come. I need rest, and I might not be able to work at my chosen profession for the rest of my life. But this is the new me. This is who I am.

As I start medical leave, I’m resting physically and emotionally. I’m welcoming the realization that I cannot do what I always have done. My pain has become my teacher as I learn deep down that I truly am worth far more than what I do for a living.

https://themighty.com/2018/05/teacher-medical-leave-peripheral-neuropathy-erythromelalgia/

Friday, 18 May 2018

What Does Neuropathy Mean To You?


Today's post from brainlessblogger.net (see link below) is another personal story of life with neuropathy, inspired by Neuropathy Awareness Week and if there's one thing that week does, it results in accounts of real people's experiences with nerve damage appearing all over the internet - ideal for raising awareness (but still a drop in the ocean). Nevertheless, every story counts and will be read by someone who's never heard of neuropathy and in that sense these stories are very necessary. Many of you will identify with elements of this person's experiences but in the end, neuropathy remains a disease that is unique to every individual - not so much in the symptoms (they're pretty much standard), or even in the treatments and therapies, but in the way each person's life is taken over by neuropathy. You'll read things here that you've also experienced but will also have many other things in your locker that may help someone if you put your own story out there.

 
Peripheral Neuropathy Awareness week 
May 12, 2018 Nikki

It is peripheral neuropathy awareness week (May 6-12).

I almost missed it because I swore up and down it was in November, but someone on my Facebook Page mentioned it. So here we are!
My story

So I have had peripheral neuropathy for years. I’d say it is idiopathic because they just speculate about the cause. However, I do have fibromyalgia and that is pretty comorbid. The neuro speculated it was caused by the status migraine I had. But that is bull. Because while a status migraine is risky… it raises the risk of stroke and heart attack. It doesn’t cause permanent nerve damage. So I call it idiopathic since no one looked into it. Or treated it. Or did anything at all aside from telling me what it was. Bravo! Docs.

I had this status migraine that lasted for more than a week. I was feeling rough, man. I went to bed… and woke up with half my right hand numb. Like a thick numbness. Not a migraine aura… to deep. Starting at the pinkie and going to mid-finger… through the palm and down to the wrist. I ignored it. Because maybe from the wicked persistent migraine? And over the course of a week, it spread, just seeping across my hand. By the time it had reached the last finger… it was also starting on the left hand.

But it then stopped getting worse. So my left hand, got a bit better actually, it is just extremely sensitive on the two fingers and part of the hand it affected temperature wise. But the right hand? Well, it is completely affected and the two first fingers that got hit first actually have some motor damage and don’t work well anymore. The rest of the hand is numb, prickly, and if I use it a lot, it hurts like hell. Now the feeling is more ‘glove-like’ and less this deep numbness. I am, of course, right-handed so this was just awesome. My writing, which always has been messy, is pretty much illegible now. And I had to learn how much pressure to put on things. I would pick up a can of pop but since I can’t feel well, I’d drop it. Ironically, this all developed While on Lyrica (for fibromyalgia)… so so much for that helping.

My mom has peripheral neuropathy as well. But in her case, not idiopathic, but from chemotherapy treatments. She has it in her feet which isn’t a fun place because that is one area always having pressure on it. As a result, she cannot wear socks and has a real problem with most shoes. The prickling pain for my mom is pretty bad. For me, it was severe but has diminished over time. Maybe from the B12 I take, maybe just random. But if it is the B12, it took years to help. But I take a good bit of it now.


Here are the symptoms of peripheral neuropathy

 
That glove-like sensation. Or sock-like sensation.
Burning sensation or a cold, sharp pain
Tingling, prickling sensations
Sharp, electrical-like pain (common for me when I use my hand for writing and what-not)
Sensitivity to touch. Just really hyper-sensitive
Muscle weakness and loss of coordination. As well as muscle cramping.
Abnormalities in blood pressure, and/or pulse.
Unusual sweating
Hot and cold sensitivity
Like my hand, you can have motor damage along with weakness.
Numbness

It can be idiopathic peripheral neuropathy, like my case. It can be from cancer treatment, like my mom. But also with diabetes, Alcoholism, B vitamin deficiencies, as well as inflection or autoimmune diseases. And, generally, it affects both sides. I have no idea what caused mine to happen, let alone why it stopped when it reached the left hand so that only the pinkie and ring finger is affected.

I, personally, take B12 and do hand exercises for the hand peripheral neuropathy. I also take tramadol which helps with my FM, and also the hand. I test temperature with my left hand because the right has no clue what temperature things are. I don’t do dishes manually… the water is too hot. I really try to do everything on the computer rather hand handwritten. At work, they liked you to print forms and do them manually… but I couldn’t do it. For one, have to Really concentrate to write in a way people can understand. And even that, is far from neat. And doing that all day? Lot of pain. So I did everything on the computer. Now that I am in a part-time role as a bank teller… I have less of a choice in this and it makes it tricky. Especially with drafts that you have to fill out for the customer. And the customer gets ticked when you ask them to fill it out themselves. So I have to do it, and damn, so hard to write clearly enough. I know they can tell I am extremely slow at it, but slow is better than illegible.

The pain really fluctuates. When I use the had a lot, obviously, but other times for no reason at all.


Related posts:

Small-fiber neuropathy and fibromyalgia

small-fiber polyneuropathy and fibromyalgia

Paresthesia and Fibromyalgia

https://brainlessblogger.net/2018/05/12/peripheral-neuropathy-awareness-week/